Alterations in high-density lipoprotein proteome and function associated with persistent organic pollutants

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• 作者：Stefan A. Ljunggren^a ; ^{stefan.ljunggren@liu.se} ; Ingela Helmfrid^a ; ^{ingela.helmfrid@regionostergotland.se} ; Ulf Norinder^b ; ^{ulf.norinder@swetox.se} ; Mats Fredriksson^c ; ^{mats.fredriksson@liu.se} ; Gun Wingren^c ; ^{gun.wingren@liu.se} ; Helen Karlsson^a ; ^{helen.m.karlsson@liu.se} ; Mats Lindahl^c ; ^{mats.lindahl@liu.se}
• 关键词：Apo ; apolipoprotein ; CETP ; cholesteryl ester transfer protein ; CVD ; cardiovascular disease ; DCFH ; 2 ; 7-dichlorofluorescin ; DCF ; 2 ; 7-dichlorofluorescein ; GO ; gene ontology ; HDL ; high-density lipoprotein ; HDL-C ; HDL cholesterol ; HOI ; HDL oxidant index ; LDL ; low-density lipoprotein ; LDL-C ; low-density lipoprotein cholesterol ; MS ; mass spectrometry ; OCPs ; organochlorine pesticides ; PCB ; polychlorinated biphenyl ; PON1 ; serum paraoxonase/arylesterase 1 ; POP ; persistent organic pollutant ; PLS ; partial l
• 刊名：Environment International
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：98
• 期：Complete
• 页码：204-211
• 全文大小：491 K
• 卷排序：98

文摘

Persistent organic pollutants (POPs) were associated with changes in HDL proteome. Up-regulated proteins were involved in HDL lipoprotein metabolic processes. Down-regulated proteins were involved in several protective functions of HDL. POPs were associated with markers of dysfunctional HDL.