Synthetic peptide antigens derived from long-chain alpha-neurotoxins: Immunogenicity effect against elapid venoms

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• 作者：Guillermo de la Rosa^a ; Nina Pastor^b ; Alejandro Alagó ; n^a ; Gerardo Corzo^a ; ^{corzo@ibt.unam.mx}
• 关键词：Elapid antivenom ; Long-chain α-neurotoxins ; Snakebites ; Three-finger toxins
• 刊名：Peptides
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：88
• 期：Complete
• 页码：80-86
• 全文大小：1427 K
• 卷排序：88

文摘

Peptides derived from the conserved motifs of long-chain a-neurotoxins are able to elicit positive humoral response in rabbits. Synthetic peptides generate neutralizing antibodies. Venoms of Naja haje, Dendroaspispolylepis and Ophiophagus hannah are partially neutralized by the antisera in a dose-depended manner. Depletion of the curare-mimetic activity of the long-chain a-neurotoxins shows the relevance of its toxicity on the overall lethality of the venoms.