Growth-inhibitory effects of a mineralized extract from the red marine algae, Lithothamnion calcareum

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• 作者：Muhammad Nadeem Aslam ; Narasimharao Bhagavathula ; Tejaswi Paruchuri ; Xin Hu ; Subhas Chakrabarty ; James Varani
• 关键词：Calcium ; Colon cancer ; Lithothamnion calcareum ; Red algae extract
• 刊名：Cancer Letters
• 出版年：2009
• 出版时间：8 October 2009
• 年：2009
• 卷：283
• 期：2
• 页码：186-192
• 全文大小：1632 K

文摘

Proliferation and differentiation were assessed in a series of human colon carcinoma cell lines in response to a mineral-rich extract derived from the red marine algae, Lithothamnion calcareum. The extract contains 12 % Ca²⁺, 1 % Mg²⁺, and detectable amounts of 72 trace elements, but essentially no organic material. The red algae extract was as effective as inorganic Ca²⁺ alone in suppressing growth and inducing differentiation of colon carcinoma cells that are responsive to a physiological level of extracellular Ca²⁺ (1.4 mM). However, with cells that are resistant to Ca²⁺ alone, the extract was still able to reduce proliferation and stimulate differentiation.