Refractive index mapping of single cells with a graphene-based optical sensor

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• 作者：Lixun Sun^aAuthor Vitae ; Yuquan Zhang^bAuthor Vitae ; Yijia Wang^cAuthor Vitae ; Chonglei Zhang^bAuthor Vitae ; Changjun Min^bAuthor Vitae ; Yong Yang^a ; ^{yangyong@nankai.edu.cn}Author Vitae ; Siwei Zhu^cAuthor Vitae ; Xiaocong Yuan^b ; ^{xcyuan@szu.edu.cn}Author Vitae
• 关键词：Refractive index mapping ; Graphene optical sensor ; Cell
• 刊名：Sensors and Actuators B: Chemical
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：242
• 期：Complete
• 页码：41-46
• 全文大小：2185 K
• 卷排序：242

文摘

Cell refractive index mapping is realized in a focused scanning structure based on the polarization-sensitive light absorption of graphene. Large longitudinal detection depth of the graphene evanescent field enables high quality cell refractive index measurement. Perfect optical vortex beam is theoretically simulated and experimentally generated, to control the focusing angles. Refractive index difference of two human colonic cancer cells is obtained from mapping image by the proposed method, which could be applied in the early diagnosis and prevention of cancer.