SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer

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• 作者：Jia You^a ; Jia Liu^a ; Yantao Bao^a ; Liqun Wang^a ; Yang Yu^a ; ^b ; Lei Wang^a ; ^c ; Di Wu^a ; Chang Liu^a ; Nan Wang^a ; Fei Wang^a ; Falin Wang^a ; Lu Xu^a ; Xing Tian^a ; Hongbin Liang^a ; Yating Gao^a ; Rongwei Guan^a ; Jing Bai^a ; Xiangning Meng^a ; Wenjing Sun^a ; Xin-Yuan Guan^d ; ^e ; Chunyu Zhang^a ; ^{zhangcy@ems.hrbmu.edu.cn} ; Songbin Fu^a ; ^f ; ^{fusb@ems.hrbmu.edu.cn} ; Yan Jin^a ; ^{jinyan@ems.hrbmu.edu.cn}
• 关键词：SEI1 ; SERTAD1 ; Genomic instability ; DDR ; Ovarian cancer
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：271-279
• 全文大小：2441 K
• 卷排序：385

文摘

SEI1 is frequently overexpressed in ovarian cancer and associated with tumor stage. Overexpression of SEI1 is associated with genomic instability. SEI1 is co-located with components of DDR complex in ovarian cancer cell line. SEI1 changes the distribution of DDR related proteins, increased genomic instability.