The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells

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• 作者：Qiong Wang¹ ; ⁶ ; Yilong Zou¹ ; ⁶ ; Sonja Nowotschin² ; Sang Yong Kim³ ; Qing V. Li² ; ⁵ ; Chew-Li Soh² ; Jie Su¹ ; Chao Zhang⁴ ; Weiping Shu¹ ; Qiaoran Xi¹ ; ⁷ ; Danwei Huangfu² ; Anna-Katerina Hadjantonakis² ; Joan Massagué ; ¹ ; ⁸ ; ^{j-massague@ski.mskcc.org}
• 关键词：p53 tumor suppressor ; Smad ; Tcf ; TGF-β ; Wnt ; mesendoderm differentiation ; transcription ; embryonic stem cells
• 刊名：Cell Stem Cell
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：20
• 期：1
• 页码：70-86
• 全文大小：4416 K
• 卷排序：20

文摘

p53/63/73 family proteins redundantly enable mesendodermal differentiation of ESCs p53/63/73 triple knockout leads to early defects in mouse embryo development The p53 family activates Wnt expression and licenses mesendodermal differentiation p53-Wnt-Tcf3 and Nodal-Smad2/3 pathways jointly activate mesendodermal enhancers