Structure activity relationship studies on cytotoxicity and the effects on steroid receptors of AB-functionalized cholestanes
详细信息 查看全文
- 作者：Lucie Rá ; rová ; a ; 1 ; lucie.rarova@upol.cz" class="auth_mail" title="E-mail the corresponding author ; Jana Steigerová ; b ; c ; 1 ; jana.steigerova@seznam.cz" class="auth_mail" title="E-mail the corresponding author ; Miroslav Kvasnicad ; mirek.kv@seznam.cz" class="auth_mail" title="E-mail the corresponding author ; Petr Bartůněke ; petr.bartunek@img.cas.cz" class="auth_mail" title="E-mail the corresponding author ; Kateřina Kří ; žová ; b ; c ; k.krizova@upol.cz" class="auth_mail" title="E-mail the corresponding author ; Hana Chodounská ; f ; hchod@uochb.cas.cz" class="auth_mail" title="E-mail the corresponding author ; Zdeněk Kolá ; řb ; zdenek.kolar@upol.cz" class="auth_mail" title="E-mail the corresponding author ; David Sedlá ; ke ; david.sedlak@img.cas.cz" class="auth_mail" title="E-mail the corresponding author ; Jana Oklestkovad ; jana.oklestkova@upol.cz" class="auth_mail" title="E-mail the corresponding author ; jana.oklestkova@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Miroslav Strnadd ; miroslav.strnad@upol.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ac-DEVD-AMC ; N-acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin ; Ac-DEVD-CHO ; N-acetyl-Asp-Glu-Val-Asp-al ; AR ; androgen receptor ; BR ; brassinosteroid ; CHAPS ; 3[(3-cholamidopropyl)dimethylammonio]-propanesulphonic acid ; DAPI ; 4&prime ; 6-diamidine-2&prime ; -phenylindole dihydrochloride ; DMEM ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium ; DMSO ; dimethylsulphoxide ; DTT ; dithiothreitol ; EC ; epoxide cholesterol ; EC50 ; half maximal effective concentration ; EDTA ; ethylene diamine tetraacetic acid ; EGTA
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：159
- 期：Complete
- 页码：154-169
- 全文大小：3556 K
文摘
- •
Structure-activity relationships of AB-functionalized cholestanes were determined.
- •
The interaction with steroid hormone receptors was observed.
- •
Derivatives influenced cell proliferation, cell cycle distribution and apoptosis.
- •
A six-membered B ring is needed for the highest cytotoxicity.