Recent Advances in Lipid-Based Vesicles and Particulate Carriers for Topical and Transdermal Application

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• 作者：Shashank Jain¹ ; ^{shashank52@gmail.com} ; Niketkumar Patel² ; Mansi K. Shah³ ; Pinak Khatri⁴ ; Namrata Vora⁵
• 关键词：liposomes ; nanoparticles ; drug delivery systems ; transdermal drug delivery ; permeability ; percutaneous ; controlled release ; colloid ; skin ; lipids
• 刊名：Journal of Pharmaceutical Sciences
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：106
• 期：2
• 页码：423-445
• 全文大小：1692 K
• 卷排序：106

文摘

In the recent decade, skin delivery (topical and transdermal) has gained an unprecedented popularity, especially due to increased incidences of chronic skin diseases, demand for targeted and patient compliant delivery, and interest in life cycle management strategies among pharmaceutical companies. Literature review of recent publications indicates that among various skin delivery systems, lipid-based delivery systems (vesicular carriers and lipid particulate systems) have been the most successful. Vesicular carriers consist of liposomes, ultradeformable liposomes, and ethosomes, while lipid particulate systems consist of lipospheres, solid lipid nanoparticles, and nanostructured lipid carriers. These systems can increase the skin drug transport by improving drug solubilization in the formulation, drug partitioning into the skin, and fluidizing skin lipids. Considering that lipid-based delivery systems are regarded as safe and efficient, they are proving to be an attractive delivery strategy for the pharmaceutical as well as cosmeceutical drug substances. However, development of these delivery systems requires comprehensive understanding of physicochemical characteristics of drug and delivery carriers, formulation and process variables, mechanism of skin delivery, recent technological advancements, specific limitations, and regulatory considerations. Therefore, this review article encompasses recent research advances addressing the aforementioned issues.