Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice
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- 作者：George Stratigopoulos1 ; gs2172@columbia.edu" class="auth_mail ; Jayne F. Martin Carli1 ; 3 ; Diana R. O&rsquo ; Day2 ; 3 ; Liheng Wang1 ; Charles A. LeDuc1 ; Patricia Lanzano1 ; Wendy K. Chung1 ; Michael Rosenbaum1 ; Dieter Egli1 ; Daniel A. Doherty2 ; Rudolph L. Leibel1 ; rl232@columbia.edu" class="auth_mail
- 刊名：Cell Metabolism
- 出版年：6 May 2014
- 年：2014
- 卷：19
- 期：5
- 页码：767-779
- 全文大小：5141 K
文摘
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Mice heterozygous for a null Rpgrip1l allele are fatter than wild-type controls
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Leptin signaling is diminished in the hypothalami of Rpgrip1l+/− mice
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The localization of the leptin receptor is perturbed in Rpgrip1l+/− mice
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RPGRIP1L may account for part or all of the association of the FTO locus with BMI
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