Cytokine decoy and scavenger receptors as key regulators of immunity and inflammation

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• 作者：Raffaella Bonecchi^a ; ^b ; ¹ ; Cecilia Garlanda^a ; ¹ ; Alberto Mantovani^a ; ^b ; ¹ ; ^{alberto.mantovani@humanitasresearch.it" class="auth_mail" title="E-mail the corresponding author} ; Federica Riva^c ; ¹
• 关键词：Chemokine ; Atypical chemokine receptor ; Regulation of inflammation ; Interleukin-1 ; Innate immunity
• 刊名：Cytokine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：87
• 期：Complete
• 页码：37-45
• 全文大小：1191 K

文摘

IL-1R2 was the first decoy receptor to be described. Subsequently receptors which act as pure decoys or scavengers or trigger dampening of cytokine signaling have been described for cytokines and chemokines. Here we review the current understanding of the mode of action and significance in pathology of the chemokine atypical receptor ACKR2, the IL-1 decoy receptor IL-1R2 and the atypical IL-1 receptor family IL-1R8. Decoy and scavenger receptors with no or atypical signaling have emerged as a general strategy conserved in evolution to tune the action of cytokines, chemokines and growth factors.