CRAM-A indicates IFN-γ-associated inflammatory response in breast cancer
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- 作者：Parisa Sarmadia ; Gurcan Tunalia ; Guldal Esendagli-Yilmazb ; Kerim Bora Yilmazc ; Gunes Esendaglia ; gunes.esendagli@lycos.com" class="auth_mail" title="E-mail the corresponding author ; gunese@hacettepe.edu.tr" class="auth_mail" title="E-mail the corresponding author
- 关键词：7TM ; seven transmembrane-spanning ; ACKR ; atypical chemokine receptor ; B-CLL ; B-cell chronic lymphocytic leukemia ; CCRL ; C&ndash ; C chemokine receptor-like ; CRAM ; chemokine receptor on activated macrophages ; EGFP ; enhanced green fluorescent protein ; ER ; estrogen receptor ; IFN ; interferon ; IHC ; immunohistochemistry ; IL ; interleukin ; MFI ; mean fluorescence intensity ; LPS ; lipopolysaccharide ; ORF ; open reading frame ; PCR ; polymerase chain reaction ; PR ; progesterone receptor ; RT ; reverse transcriptase
- 刊名：Molecular Immunology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：68
- 期：2
- 页码：692-698
- 全文大小：1487 K
文摘
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The atypical chemokine receptor CCRL2 is constitutively expressed in breast cancer.
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CCRL2 expression is specific to malignant epithelium and inflammatory status.
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The rare isoform of CCRL2, CRAM-A is specifically upregulated upon IFN-γ exposure.
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CRAM-A marks inflammation and may serve as an immune modulator in breast cancer.