Association of lung cancer with skin diseases: A nationwide cohort study based on the “lung governing skin and hair” theory

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• 作者：Chia-Man Ma^a ; ^{cutegladys0708@gmail.com} ; Jui-Lung Shen^a ; ^b ; ^{shen5300@yahoo.com.tw} ; Cheng-Li Lin^c ; ^{orangechengli@gmail.com} ; Kao-Sung Tsai^c ; ^d ; ^e ; ^{raysclinic@gmail.com} ; San-Yuan Wu^d ; ^{wukuo333@yahoo.com.tw} ; Huey-Yi Chen^c ; ^d ; ^{d888208@ms45.hinet.net} ; Kee-Ming Man^f ; ^g ; ^{man_jimmy60@hotmail.com} ; Yung-Hsiang Chen^c ; ^d ; ^h ; ^{yhchen@mail.cmu.edu.tw} ; Wen-Chi Chen^c ; ^d ; ^{wgchen@mail.cmu.edu.tw}
• 关键词：TCM ; traditional Chinese medicine ; NHI ; National Health Insurance ; LHID ; Longitudinal Health Insurance Database ; ICD-9-CM ; International Classification of Disease 9th Revision of the Clinical Modification ; COPD ; chronic obstructive pulmonary disease ; CAD ; coronary artery disease ; SD ; standard deviation ; HRs ; hazard ratios ; CIs ; confidence intervals
• 刊名：European Journal of Integrative Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：8
• 期：6
• 页码：952-957
• 全文大小：481 K
• 卷排序：8

文摘

This population-based cohort study based on the “lung governing skin and hair” theory of traditional Chinese medicine (TCM) to investigate the association of lung cancer with non-eczema skin and subcutaneous diseases.MethodsBy using the Taiwan National Health Insurance Research Database, we identified 13,034 patients who had been newly diagnosed with non-eczema skin and subcutaneous diseases from 2000 to 2010. 26,068 age-matched patients without non-eczema skin and subcutaneous diseases were randomly selected as the comparison cohort.ResultsThe mean follow-up of the non-eczema skin and subcutaneous disease cohort was 7.66 years and control cohort was 7.53 years, respectively. The cumulative incidence of lung cancer was higher in the non-eczema skin and subcutaneous disease cohort than that in the control cohort by 2.89% at the end of follow-up. The non-eczema skin and subcutaneous disease cohort had a higher lung cancer incidence than the control cohort. The non-eczema skin and subcutaneous disease patients with or without comorbidity were associated with lung cancer.ConclusionsThese results suggest that non-eczematous skin and subcutaneous diseases is associated with lung cancer, thus supporting the lung governing skin and hair theory of TCM.