Intensive statin regimens for reducing risk of cardiovascular diseases among human immunodeficiency virus-infected population: A nation-wide longitudinal cohort study 2000-2011

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• 作者：Huang-tz Ou^a ; ^b ; Kai-Cheng Chang^a ; ^c ; Chung-Yi Li^d ; ^e ; Chen-Yi Yang^a ; Nai-Ying Ko^f ; ^g ; ^{nyko@mail.ncku.edu.tw}
• 关键词：Human immunodeficiency virus (HIV) ; Cardiovascular diseases ; Statin ; Dose-response ; Intensive regimens
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：230
• 期：Complete
• 页码：592-598
• 全文大小：633 K
• 卷排序：230

文摘

The cardiovascular disease (CVD) rate was 7.29 per 1000 person-years for HIV patients in Taiwan over 12-years of follow-up. The CVD rate for the HIV patients without CVD history was 0.63 per 1000 per person-years over 12-years of follow-up. Male and younger (< 40 years) HIV patients were found to experience a higher CVD rate. Intensive statin regimens are effective in reducing CVD risks for HIV patients; high-potency treatment may reduce CVD risks. A dose-dependent relationship between statin and CVD risks is supported; higher dose was associated with lower CVD risks.