Kr眉ppel-like factor 14 increases insulin sensitivity through activation of PI3K/Akt signal pathway
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- 作者：Min Yanga ; 1 ; Yan Rena ; 1 ; Zhimin Linb ; 1 ; Chenchen Tangb ; 1 ; Yanjun Jiab ; Yerui Laib ; Tingting Zhoub ; Shaobo Wua ; Hua Liuc ; Gangyi Yangb ; Ling Lia ; liling31@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Krü ; ppel-like factor 14 ; The PI3K/Akt pathway ; Insulin resistance
- 刊名：Cellular Signalling
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：27
- 期：11
- 页码：2201-2208
- 全文大小：1099 K
文摘
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Genome-wide association studies have shown that KLF14 is associated with T2DM.
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It is the first report of KLF14 in glucose metabolism and insulin signaling pathway.
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We investigated the expressions of KLF14 in mice and T2DM subjects.
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We evaluated the effects of KLF14 on glucose uptake and insulin signaling.
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KLF14 might increase insulin sensitivity through the PI3K/Akt pathway.