MicroRNA-203-mediated posttranscriptional deregulation of CPEB4 contributes to colorectal cancer progression
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- 作者：Xiaohua Zhong1 ; Yipin Xiao1 ; Chao Chen ; chenchaopw@126.com" class="auth_mail" title="E-mail the corresponding author ; Xiuwen Wei ; Chen Hu ; Xukun Ling ; Xinbin Liu
- 关键词：CPEB4 ; Colorectal cancer ; Apoptosis ; miR-203 ; Proliferation
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：16 October 2015
- 年：2015
- 卷：466
- 期：2
- 页码：206-213
- 全文大小：2027 K
文摘
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CPEB4 is aberrantly expressed in human colorectal cancers.
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Knockdown of CPEB4 inhibited colorectal cancer cell proliferation and enhanced apoptosis.
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CPEB4 is a direct target of miR-203 and inversely correlates with miR-203 expression.
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miR-203 inhibited cell growth and enhanced cell apoptosis in CPEB4 dependent manner.
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miR-203 is an upstream regulator of the CPEB4-induced apoptosis pathway.