Decreased myeloid dendritic cells indicate a poor prognosis in patients with severe fever with thrombocytopenia syndrome

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• 作者：Wenjing Zhang^a ; ^c ; Mengmeng Li^a ; ^c ; Shue Xiong^a ; Hua Wang^a ; Yan Xiong^a ; Mingyue Li^a ; Mengji Lu^b ; Dongliang Yang^a ; Cheng Peng^a ; ^{Drpengcheng@hust.edu.cn} ; Xin Zheng^a ; ^{xin11@hotmail.com}
• 关键词：Severe fever with thrombocytopenia syndrome ; Acute phase ; Mortality ; Dendritic cell ; Prognosis
• 刊名：International Journal of Infectious Diseases
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：Complete
• 页码：113-120
• 全文大小：1889 K
• 卷排序：54

文摘

This is the first study to report the frequencies and activation status of circulating dendritic cells (DCs) in patients at different stages of severe fever with thrombocytopenia syndrome (SFTS). The decreased percentage of DCs in peripheral blood mononuclear cells (PBMCs) was correlated with the severity of SFTS. The circulating level of myeloid dendritic cells (mDCs) can be used as a valuable prognostic biomarker for SFTS patients. These findings lead to a better understanding of the mechanisms underlying the progression of SFTS.