Natural product-based design, synthesis and biological evaluation of Albiziabioside A derivatives that selectively induce HCT116 cell death
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- 作者：Gaofei Wei ; Shanshan Cui ; Weijing Luan ; Shuai Wang ; Zhuang Hou ; Yongxiang Liu ; Yang Liu ; y.liu@syphu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Maosheng Cheng ; mscheng@syphu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Albiziabioside A ; Saponin ; Cinnamoyl ; Anti-proliferative activities ; Cell cycle arrest ; Apoptosis
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：4 May 2016
- 年：2016
- 卷：113
- 期：Complete
- 页码：92-101
- 全文大小：1461 K
文摘
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A series of Albiziabioside A derivatives substituted with cinnamoyl groups were designed and synthesized.
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The compound 8n was found with much less cytotoxicity towards normal cells lines.
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The anti-proliferative activity of 8n could be attributed to the induction of cell cycle arrest and apoptosis in HCT116 cells.