Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility
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- 作者：Chengji Piaoa ; b ; c ; Xiaofei Denga ; b ; 1 ; Xingyue Wanga ; b ; 1 ; Yiran Yuand ; Zhengkui Liua ; Jing Lianga ; liangj@psych.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Single prolonged stress ; Set-shifting ; Medial prefrontal cortex ; Nucleus accumbens
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：16-26
- 全文大小：3045 K
文摘
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Single prolonged stress (SPS) impaired set-shifting.
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SPS-induced set-shifting impairments coincided with activity reduction in NAc core.
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Neurons in mPFC exhibited higher activity in SPS-induced set-shifting dysfunction.
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Enhanced phospho-GluA1-Ser845 in mPFC was related to the impaired set-shifting.