NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum
详细信息 查看全文
- 作者：Keqiang Xie1 ; Lesley A. Colgan2 ; Maria T. Dao3 ; Brian S. Muntean1 ; Laurie P. Sutton1 ; Cesare Orlandi1 ; Sanford L. Boye4 ; Shannon E. Boye4 ; Chien-Cheng Shih1 ; Yuqing Li5 ; Baoji Xu1 ; Roy G. Smith3 ; Ryohei Yasuda2 ; Kirill A. Martemyanov1 ; 6 ; kirill@scripps.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：striatum ; G proteins ; GPCR signaling ; neurofibromatosis ; opioids ; addiction
- 刊名：Current Biology
- 出版年：2016
- 出版时间：21 November 2016
- 年：2016
- 卷：26
- 期：22
- 页码：2992-3003
- 全文大小：2188 K
文摘
- •
NF1 is a direct G protein effector inhibited by the Gβγ subunits
- •
Activation of the Ras-Akt-mTOR axis by opioid receptors in the striatum requires NF1
- •
Opioid receptors activate Ras only in direct pathway striatal neurons
- •
NF1 in striatal neurons regulates morphine reward