Transcriptional gene silencing of dopamine D3 receptor caused by let-7d mimics in immortalized renal proximal tubule cells of rats
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- 作者：Ye Zhang ; Caiyu Cheng ; Duofen He ; Weibin Shi ; Chunjiang Fu ; Xukai Wang ; Chunyu Zeng ; chunyuzeng01@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：TGS ; transcriptional gene silencing ; siRNA ; short interfering RNA ; miRNA ; microRNA ; DRD3 ; dopamine D3 receptor ; RPT ; renal proximal tubule ; DNMT ; DNA-methyltransferase ; DNMT1 ; DNA-methyltransferase 1 ; DNMT3b ; DNA-methyltransferase 3b ; 5-aza-dc ; 5&prime ; -aza-2&prime ; -deoxycytidine ; H3K9me2 ; H3 lysine 9 dimethylation ; H3K27me3 ; H3 lysine 27 trimethylation ; AGO ; Argonaute ; PTGS ; post-transcriptional gene silencing ; ncRNA ; non-coding RNA ; RITS ; RNA induced transcriptional silencing ; HDAC ; histone de
- 刊名：Gene
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：580
- 期：2
- 页码：89-95
- 全文大小：575 K
文摘
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We demonstrated that let-7d mimics induced DRD3 repression in a transcriptional manner.
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Let-7d mimics induced DRD3 transcription and was associated to the recruitment of AGO2.
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Let-7d mimics induced DRD3 transcriptional repression via DNMT1 and DNMT3b dependent DNA methylation.
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H3K9me2 is involved in the let-7d induced DRD3 transcriptional gene silencing.