APT2 Inhibition Restores Scribble Localization and S-Palmitoylation in Snail-Transformed Cells

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• 作者：Jeannie L. Hernandez¹ ; ³ ; Dahvid Davda¹ ; ² ; ³ ; Melanie Cheung See Kit¹ ; Jaimeen D. Majmudar¹ ; Sang Joon Won² ; Margery Gang¹ ; Sirisha C. Pasupuleti¹ ; Alexandria I. Choi¹ ; Callie M. Bartkowiak¹ ; Brent R. Martin¹ ; ² ; ⁴ ; ^{brentrm@umich.edu}
• 关键词：protein palmitoylation ; cell polarity ; hydrolase ; inhibitor ; fluorescence imaging ; epithelial-mesenchymal transition ; activity-based profiling
• 刊名：Cell Chemical Biology
• 出版年：2017
• 出版时间：19 January 2017
• 年：2017
• 卷：24
• 期：1
• 页码：87-97
• 全文大小：3071 K
• 卷排序：24

文摘

Scribble S-palmitoylation is reduced after overexpression of Snail Snail overexpression reduces levels of select zDHHC protein acyl transferases After Snail overexpression, APT2 inhibition rescues Scribble localization MEK activation is attenuated following APT2 inhibition in Snail-expressing cells