Do nanoparticles have a future in dermal drug delivery?

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• 作者：Alexa Patzelt^a ; ¹ ; ^{alexa.patzelt@charite.de} ; Wing Cheung Mak^c ; ^d ; ¹ ; ^{wing.cheung.mak@liu.se} ; Sora Jung^a ; ^{sora.jung@charite.de} ; Fanny Knorr^a ; ^{fanny.knorr@charite.de} ; Martina C. Meinke^a ; ^{martina.meinke@charite.de} ; Heike Richter^a ; ^{heike.richter@charite.de} ; Eckart Rü ; hl^b ; ^{ruehl@zedat.fu-berlin.de} ; Kwan Yee Cheung^c ; ^{kwan.yee.cheung@liu.se} ; Ngo Bich Nga Nathalie Tran^a ; ^{nathalie.tran@outlook.com} ; Jü ; rgen Lademann^a ; ^{juergen.lademann@charite.de}
• 关键词：Skin barrier ; Penetration ; Hair follicle ; Triggered drug release ; Laser scanning microscopy ; Differential stripping
• 刊名：Journal of Controlled Release
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：246
• 期：Complete
• 页码：174-182
• 全文大小：888 K
• 卷排序：246

文摘

BSA particles represent smart nanoparticle systems which can be equipped with different mechanisms for the release of the loaded drug within the hair follicle. A release of the model drug within the hair could be detected for all three nanoparticle systems, for the protease-triggered controlled release BSA nanoparticles and the IR-triggered controlled release AuNP-doped BSA nanoparticles even an uptake of the model drug in the sebaceous gland could be detected. Nanoparticles can be very useful in dermal drug delivery if smart nanoparticle systems are utilized which are able to release their drug at specific times and locations within the hair follicle where the released drug can then penetrate independently in the follicle-surrounding tissue.