Lipoic acid and haloperidol-induced vacuous chewing movements: Implications for prophylactic antioxidant use in tardive dyskinesia
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- 作者：Joshua Lister ; MSca ; b ; Ana C. Andreazzaa ; b ; c ; e ; Bushra Navaide ; Virginia S. Wilsona ; Celine Teoa ; Yasika Nesarajaha ; Alan A. Wilsona ; c ; José ; N. Nobregaa ; c ; d ; e ; Paul J. Fletchera ; c ; d ; Gary Remingtona ; b ; c ; gary.remington@camh.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tardive dyskinesia ; Animal models ; Antipsychotics ; Psychopharmacology
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2017
- 出版时间：4 January 2017
- 年：2017
- 卷：72
- 期：Complete
- 页码：23-29
- 全文大小：611 K
文摘
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Oxidative stress has been implicated in antipsychotic-related tardive dyskinesia (TD).
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Prophylactic antioxidant represents a possible treatment option in preventing TD.
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In a rodent model, this was not observed with concomitant use of lipoic acid in haloperidol-treated animals.