Salvianolic acid A alleviates ischemic brain injury through the inhibition of inflammation and apoptosis and the promotion of neurogenesis in mice
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- 作者：Mei-Yin Chienb ; l ; Cheng-Hung Chuangc ; Chang-Ming Chernf ; g ; Kou-Tong Lioum ; Der-Zen Liue ; h ; 1 ; tonyliu@tmu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Yu-Chang Houd ; i ; 1 ; Yuh-Chiang Shena ; j ; k ; 1 ; yuhcs@nricm.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：BBB ; blood-brain barrier ; Bcl-2 ; B-cell lymphoma 2 ; Cdk5 ; cyclin-dependent kinase 5 ; DCX ; doublecortin ; GSK3 ; glycogen synthase kinase 3 ; MCAO ; middle cerebral artery occlusion/reperfusion ; NF-κB ; nuclear factor-kappa B ; SalA ; salvianolic acid A
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：508-519
- 全文大小：6638 K
文摘
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BDNF upregulation by SalA causes activation of the PI3K/Akt pathway.
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Inhibition of GSK-3 pathways for anti-apoptosis and neurogenesis by SalA.
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Prevention of p25 production/Cdk5 activation by SalA is beneficial in stroke.
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