Hyperuricemia Associated With Rapid Renal Function Decline in Elderly Taiwanese Subjects

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• 作者：Chung-Jen Yen ; Chih-Kang Chiang ; Li-Chun Ho ; S ; y Huey-Jen Hsu ; Kuan-Yu Hung ; Kwan-Dun Wu ; Tun-Jun Tsai
• 关键词：aged ; chronic kidney disease ; glomerular filtration rate ; hyperuricemia ; Taiwan
• 刊名：Journal of the Formosan Medical Association
• 出版年：2009
• 出版时间：December 2009
• 年：2009
• 卷：108
• 期：12
• 页码：921-928
• 全文大小：220 K

文摘

Background/Purpose

Hyperuricemia is encountered frequently in patients with chronic kidney disease (CKD). We tested the hypothesis that uric acid influences glomerular filtration rate (GFR) and is associated with renal function decline in elderly Taiwanese subjects.

Methods

We enrolled 800 elderly Taiwanese subjects for a health checkup. Estimated GFR (eGFR) was measured using the Modification of Diet in Renal Disease Study equation. eGFR < 60 mL/min/1.73 m² was used to analyze the prevalence and incidence of CKD. Significant renal function decline was defined as a decrease in eGFR of ≥ 3 mL/min/1.73 m² per year.

Results

The prevalence of CKD was 18.0 % in the elderly subjects. Mean serum uric acid level was 6.6 mg/dL in male and 5.6 mg/dL in female subjects, and eGFR was 71.7 mL/min/1.73 m². Uric acid levels were associated independently and negatively with eGFR after adjusting for conventional factors of renal function decline. One hundred and sixty-two individuals (31.2 % ) had a significant decline in renal function. As uric acid level increased by 1 mg/dL, the odds of a significant eGFR decline increased by 1.208.

Conclusion

Serum uric acid level was associated with eGFR and decline in renal function in elderly Taiwanese subjects. Whether hypouricemic therapy could retard the progression of CKD deserves further in-depth study.