Risk factors associated with Sphingomonas paucimobilis infection

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• 作者：Han-Siong Toh^a ; Hung-Tze Tay^b ; Wei-Khie Kuar^b ; Tzu-Chieh Weng^a ; Hung-Jen Tang^a ; Che-Kim Tan^b ; ^{chekim.tan@gmail.com}
• 关键词：Bacteremia ; Community-acquired infection ; Sphingomonas paucimobilis
• 刊名：Journal of Microbiology, Immunology and Infection
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：44
• 期：4
• 页码：289-295
• 全文大小：158 K

文摘

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Background

Sphingomonas paucimobilis is rarely isolated from clinical specimens and it is associated with a great variety of infections. The aim of this study is to investigate the microbiological and clinical features of S paucimobilis infection in southern Taiwan.

Methods

S paucimobilis isolates from the microbiology laboratory of Chi-Mei Medical Center and their relevant clinical data from October 2005 to October 2009 were retrospectively reviewed.

Results

A total of 55 patients with documented S paucimobilis infections were identified. Among them, 29 (52.7 % ) have community-acquired infections and 13 of them presented with primary bacteremia (44.8 % ). Multivariate logistic regression showed that community-acquired infection [adjusted odds ratio 13.473, 95 % confidence interval (CI) 1.79?01.41, p = 0.01], diabetes mellitus (adjusted odds ratio 7.03, 95 % CI 1.16?2.66, p = 0.03), and alcoholism (adjusted OR 10.87, 95 % CI 1.00?17.69, p = 0.05) were significant risk factors for S paucimobilis primary bacteremia. Most of those who have health care-associated S paucimobilis infections presented with pneumonia (10 of 26, 38.5 % ) and only 7.7 % presented with catheter-related infection. The overall mortality rate was 5.5 % .

Conclusion

Community-acquired S paucimobilis infections were not uncommon, mainly presenting with primary bacteremia. Multivariate analysis showed that community-acquired infection, diabetes mellitus, and alcoholism were significant risk factors for primary bacteremia.