IL-1β-induced MCP-1 expression and secretion of human dental pulp cells is related to TAK1, MEK/ERK, and PI3K/Akt signaling pathways
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- 作者：Mei-Chi Changa ; Yi-Ling Tsaib ; 1 ; Hsiao-Hua Changb ; 1 ; hhchang.pedo@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sheng-Yang Leec ; Ming-Shu Leeb ; Chun-Wei Changc ; Chiu-Po Chand ; Chien-Yang Yehb ; Ru-Hsiu Chengc ; Jiiang-Huei Jengb ; jhjeng@ntu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cyclooxygenase ; Inflammation ; Interleukin-1β ; MCP-1 ; MEK/ERK ; PI3K/Akt ; Pulp ; Signal transduction ; TAK1
- 刊名：Archives of Oral Biology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：61
- 期：Complete
- 页码：16-22
- 全文大小：1566 K
文摘
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IL-1β stimulated MCP-1 mRNA, protein expression and its secretion of pulp cells.
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IL-1β-induced MCP-1 expression is attenuated by TAK1, MEK/ERK and PI3K/Akt inhibitors.
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IL-1β-induced MCP-1 secretion is attenuated by TAK1, MEK/ERK and PI3K/Akt inhibitors.
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IL-1β plays crucial role in pulpal inflammation by stimulation of MCP-1.
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TAK1, MEK/ERK and PI3K/Akt are involved in these events.