Resection of an ameloblastoma in a pediatric patient and immediate reconstruction using a combination of tissue engineering and costochondral rib graft: A case report

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• 作者：Jeanette Johnson ; DDSAuthor Vitae ; Jonathon Jundt ; DDS ; MDAuthor Vitae ; Issa Hanna ; DDSAuthor Vitae ; Jonathan W. Shum ; DDS ; MDAuthor Vitae ; Gary Badger ; DDS ; MsDAuthor Vitae ; James C. Melville ; DDS ; ^{James.C.Melville@uth.tmc.edu}Author Vitae
• 关键词：Tissue engineering ; oral and maxillofacial surgery ; oral and maxillofacial pathology ; neoplasms ; pediatric dentistry ; oral surgical procedures ; bone grafting ; bone marrow transplantation ; bone substitutes
• 刊名：The Journal of the American Dental Association
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：148
• 期：1
• 页码：40-43
• 全文大小：1402 K
• 卷排序：148

文摘

Ameloblastoma is an odontogenic tumor predominantly occurring in patients who are in their 20s and 30s. Approximately 10% to 15% of ameloblastomas occur in patients younger than 18 years. Although it is a benign tumor, an ameloblastoma can have a devastating effect on children both physically and emotionally. The aim of this case report is to demonstrate how tissue engineering and surgical techniques can minimize morbidity and recovery time after extirpation and immediate reconstruction of a mandibular ameloblastoma.Case DescriptionAn 11-year-old girl was referred for surgical evaluation of a lesion found on a routine dental radiograph. Resection of a mandibular unicystic ameloblastoma resulted, including immediate reconstruction using a costochondral rib graft, allogeneic bone, bone marrow aspirate concentrate, and recombinant human morphogenetic protein-2. One year postoperatively, the patient had no evidence of recurrence as well as excellent mandibular bone height and width with good facial form. The patient has returned to her daily life without any disabilities or disfigurement.Conclusions and Practical ImplicationsDentists are typically the first health care providers to discover oral pathology in patients. The coordination of care by the dental care providers and the oral and maxillofacial specialist was key to the successful outcome for this patient. With biotechnology and surgical techniques, the dental surgeon can extirpate an ameloblastoma and reconstruct the mandible defect to the ideal shape and size with minimal morbidity and recovery time.