Millifluidic Lab-on-a-Chip technology for automated toxicity tests using the marine amphipod Allorchestes compressa
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- 作者：Rhys Cartlidgea ; bAuthor Vitae ; Dayanthi Nugegodab ; cAuthor Vitae ; Donald Wlodkowica ; c ; d ; 1 ; donald.wlodkowic@rmit.edu.au" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Lab-on-a-Chip ; Millifluidic ; Chip ; Automation ; Ecotoxicology ; Amphipod ; Allorchestes compressa ; Biotest ; Behavior ; Sub-Lethal
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：239
- 期：Complete
- 页码：660-670
- 全文大小：3081 K
文摘
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This work demonstrated a novel application of milifluidics in ecotoxicology.
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We developed Lab-on-a-Chip technology for perfusion toxicity testing and behavioral analysis for Allorchestes compressa.
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We developed a proof-of-concept embedded “off-chip” interface for miniaturized behavioral biotests.
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Toxicity testing with reference toxicants showed a strong correlation with results obtained from traditional methods.
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Behavioural indices of Allorchestes compressa can be used as a reliable sub-lethal endpoint.