Acidity-triggered charge-convertible nanoparticles that can cause bacterium-specific aggregation in situ to enhance photothermal ablation of focal infection

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• 作者：Chiranjeevi Korupalli^a ; ¹ ; Chieh-Cheng Huang^a ; ¹ ; Wei-Chih Lin^a ; Wen-Yu Pan^a ; Po-Yen Lin^a ; Wei-Lin Wan^a ; Meng-Ju Li^b ; Yen Chang^c ; ^{cvsyenchang@gmail.com} ; Hsing-Wen Sung^a ; ^{hwsung@mx.nthu.edu.tw}
• 关键词：Subcutaneous abscesses ; Photothermal therapy ; pH-responsive nanoparticles ; Charge conversion ; Imaging guiding
• 刊名：Biomaterials
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：116
• 期：Complete
• 页码：1-9
• 全文大小：2838 K
• 卷排序：116

文摘

Focal infections that are caused by antibiotic-resistant bacteria are becoming an ever-growing challenge to human health. To address this challenge, a pH-responsive amphiphilic polymer of polyaniline-conjugated glycol chitosan (PANI-GCS) that can self-assemble into nanoparticles (NPs) in situ is developed. The PANI-GCS NPs undergo a unique surface charge conversion that is induced by their local pH, favoring bacterium-specific aggregation without direct contact with host cells. Following conjugation onto GCS, the optical-absorbance peak of PANI is red-shifted toward the near-infrared (NIR) region, enabling PANI-GCS NPs to generate a substantial amount of heat, which is emitted to their neighborhood. The local temperature of the NIR-irradiated PANI-GCS NPs is estimated to be approximately 5 °C higher than their ambient tissue temperature, ensuring specific and direct heating of their aggregated bacteria; hence, damage to tissue is reduced and wound healing is accelerated. The above results demonstrate that PANI-GCS NPs are practical for use in the photothermal ablation of focal infections.