Chronic stress affects the number of GABAergic neurons in the orbitofrontal cortex of rats
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- 作者：Zsó ; fia Vargaa ; Dá ; vid Csabaia ; Attila Misetab ; Ove Wiborgc ; Boldizsá ; r Czé ; ha ; b ; c ; czeh.boldizsar@pte.hu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CB ; calbindin ; CCK ; cholecystokinin ; CMS ; chronic mild stress ; CR ; calretinin ; DLO ; dorsolateral orbitofrontal cortex ; GABA ; gamma-aminobutyric acid ; LO ; lateral orbitofrontal cortex ; M1 ; primary motor cortex ; MO ; medial orbitofrontal cortex ; mPFC ; medial prefrontal cortex ; NPY ; neuropeptide Y ; OFC ; orbitofrontal cortex ; PFC ; prefrontal cortex ; PV ; parvalbumin ; SST ; somatostatin ; VO ; ventral orbitofrontal cortex
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：104-114
- 全文大小：4371 K
文摘
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We used the chronic mild stress model for depression and investigated GABAergic neurons in the orbitofrontal cortex.
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We quantified calbindin-, calretinin-, cholecystokinin-, parvalbumin-, NPY- and somatostatin-positive neurons.
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We found pronounced stress-induced reduction of calbindin-positive neuron densities in the orbitofrontal cortex.
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Stress-resilient rats had increased densities of CCK+ and NPY+ cells in their ventral and lateral orbitofrontal cortex.