Similar oxysterols may lead to opposite effects on synaptic transmission: Olesoxime versus 5α-cholestan-3-one at the frog neuromuscular junction
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- 作者：M.R. Kasimov ; G.F. Zakyrjanova ; A.R. Giniatullin ; A.L. Zefirov ; A.M. Petrov ; fysio@rambler.ru" class="auth_mail" title="E-mail the corresponding author
- 关键词：ɑ-Btx ; ɑ-bungarotoxin ; 5ɑCh3 ; 5ɑ-cholestan-3-one ; bodipy-ganglioside GM1 ; BODIPY® ; FL C5-ganglioside GM1 ; MEPC ; miniature postsynaptic end-plate currents ; EPC ; postsynaptic end-plate current ; 22-NBD-cholesterol ; 22-(N-(7-nitrobenz-2-oxa-1 ; 3-diazol-4-yl)amino)-23 ; 24-bisnor-5-cholen-3β-ol ; CTxB ; subunit B from cholera toxin
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：1861
- 期：7
- 页码：606-616
- 全文大小：1270 K
文摘
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We study changes in the neurotransmission at frog neuromuscular junction.
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Olesoxime increases evoked, but not spontaneous, neurotransmitter release.
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Olesoxime increases exo-endocytosis and the rate of synaptic vesicle recycling.
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Olesoxime impacts on synaptic membrane properties/formation of lipid rafts.
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The structurally related oxysterol, 5α-cholestan-3one, has opposite actions.