Designing an efficient multi-epitope peptide vaccine against Vibrio cholerae via combined immunoinformatics and protein interaction based approaches
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- 作者：Navid Nezafata ; Zeinab Karimia ; b ; Mahboobeh Eslamia ; Milad Mohkama ; b ; Sanam Zandiana ; Younes Ghasemia ; b ; c ; ghasemiy@sums.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vibrio cholerae ; Epitope vaccine ; Protective immunity ; Adjuvant ; Bioinformatics ; Molecular dynamics simulation
- 刊名：Computational Biology and Chemistry
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：62
- 期：Complete
- 页码：82-95
- 全文大小：3504 K
文摘
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Designing epitope peptide vaccines is a novel strategy for protection against Vibrio cholerae.
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The designed cholera vaccine consists of two main sections: four protective antigens (OmpW, OmpU, TcpA and TcpF) and adjuvant (CTB).
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The selected epitopes and adjuvant were fused together by proper linkers in order to enhance the immunogenicity of vaccine.
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In silico analysis indicates that the epitope vaccine is able to incite long-lasting protective immunity against V. cholerae.