Dietary choline levels modify the effects of prenatal alcohol exposure in rats
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- 作者：Nirelia M. Idrus ; Kristen R. Breit ; Jennifer D. Thomas ; thomas3@mail.sdsu.edu
- 关键词：Fetal alcohol spectrum disorders ; Prenatal ethanol ; Open field activity ; Hindlimb coordination ; Cliff avoidance ; Choline deficiency
- 刊名：Neurotoxicology and Teratology
- 出版年：2017
- 出版时间：January-February 2017
- 年：2017
- 卷：59
- 期：Complete
- 页码：43-52
- 全文大小：1150 K
- 卷排序：59
文摘
Prenatal alcohol exposure in rats disrupted development, delaying motor development. A low choline diet during the perinatal period altered sensorimotor development. Low choline diet and alcohol severely disrupted physical and behavioral development. Suboptimal intake of choline perinatally can exacerbate ethanol's teratogenic effects.