Genetic Control over mtDNA and Its Relationship to Major Depressive Disorder
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- 作者：Na Cai1 ; Yihan Li1 ; Simon Chang2 ; Jieqin Liang3 ; Chongyun Lin3 ; Xiufei Zhang3 ; Lu Liang3 ; Jingchu Hu3 ; Wharton Chan1 ; Kenneth S. Kendler4 ; Tomas Malinauskas5 ; Guo-Jen Huang2 ; Qibin Li3 ; Richard Mott1 ; Jonathan Flint1 ; jf@well.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Biology
- 出版年：2015
- 出版时间：21 December 2015
- 年：2015
- 卷：25
- 期：24
- 页码：3170-3177
- 全文大小：2141 K
文摘
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Loci near TFAM and CDK6 contribute to variation in the amount of mtDNA
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Mutations accumulate in the mtDNA of cases of major depression
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Animal experiments show that heteroplasmy can be induced by chronic stress
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Amount of mtDNA is associated with site-specific heteroplasmy