Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System
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- 作者：John D. Murdoch1 ; 2 ; 8 ; Christine M. Rostosky1 ; 8 ; Sindhuja Gowrisankaran1 ; Amandeep S. Arora1 ; Sandra-Fausia Soukup3 ; 4 ; Ramon Vidal5 ; Vincenzo Capece5 ; Siona Freytag1 ; Andre Fischer6 ; 7 ; Patrik Verstreken3 ; 4 ; Stefan Bonn5 ; Nuno Raimundo2 ; nuno.raimundo@med.uni-goettingen.de" class="auth_mail" title="E-mail the corresponding author ; Ira Milosevic1 ; 9 ; imilose@gwdg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：endophilin ; FBXO32 ; endocytosis ; autophagy ; ubiquitin-proteasome system ; neurodegeneration ; ataxia ; Parkinson&rsquo ; s disease ; next-generation sequencing ; protein homeostasis
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：17
- 期：4
- 页码：1071-1086
- 全文大小：5831 K
文摘
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Endophilin-A is needed for autophagosome formation in mammalian neurons and brain
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Absence of endophilin-A upregulates the E3-ubiquitin ligase FBXO32
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FBXO32-endophilin-A interaction maintains neuronal health and protein homeostasis
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Endophilin-A KO mice show age-dependent ataxia, motor impairments, and neurodegeneration