Oxidative and inert pyrolysis on-line coupled to gas chromatography with mass spectrometric detection: On the pyrolysis products of tobacco additives

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• 作者：Meike Paschke ; Christoph Hutzler ; Frank Henkler ; Andreas Luch ; ^{Andreas.Luch@bfr.bund.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Acy ; acenaphthylene ; CIS ; cooled injection system ; CMR ; carcinogenic ; mutagenic ; reprotoxic ; DBA ; dibenz[a ; h]anthracene ; EPC ; electronic pneumatics control ; FEMA ; Flavour and Extract Manufacturers Association ; GC ; gas chromatography ; GRAS ; generally recognized as safe ; IARC ; International Agency for Research on Cancer ; MS ; mass spectrometry ; m/z ; mass to charge ratio ; Naph ; naphthalene ; NIST ; National Institute of Standards and Technology ; PTV ; programmed temperature vaporizing ; PAHs ; polycyclic
• 刊名：International Journal of Hygiene and Environmental Health
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：219
• 期：8
• 页码：780-791
• 全文大小：1900 K

文摘

According to European legislation, tobacco additives may not increase the toxicity or the addictive potency of the product, but there is an ongoing debate on how to reliably characterize and measure such properties. Further, too little is known on pyrolysis patterns of tobacco additives to assume that no additional toxicological risks need to be suspected. An on-line pyrolysis technique was used and coupled to gas chromatography-mass spectrometry (GC/MS) to identify the pattern of chemical species formed upon thermal decomposition of 19 different tobacco additives like raw cane sugar, licorice or cocoa. To simulate the combustion of a cigarette it was necessary to perform pyrolysis at inert conditions as well as under oxygen supply. All individual additives were pyrolyzed under inert or oxidative conditions at 350, 700 and 1000 °C, respectively, and the formation of different toxicants was monitored. We observed the generation of vinyl acrylate, fumaronitrile, methacrylic anhydride, isobutyric anhydride and 3-buten-2-ol exclusively during pyrolysis of tobacco additives. According to the literature, these toxicants so far remained undetectable in tobacco or tobacco smoke. Further, the formation of 20 selected polycyclic aromatic hydrocarbons (PAHs) with molecular weights of up to 278 Da was monitored during pyrolysis of cocoa in a semi-quantitative approach. It was shown that the adding of cocoa to tobacco had no influence on the relative amounts of the PAHs formed.