Asymmetric synthesis of (S)-carbinoxamine. New aspects of oxazaborolidine-catalyzed enantioselective carbonyl reduction
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- 作者：Corey ; E. J. ; Helal ; Christopher J.
- 刊名：Tetrahedron Letters
- 出版年：1996
- 出版时间：August 5, 1996
- 年：1996
- 卷：37
- 期：32
- 页码：5675-5678
- 全文大小：258 K
文摘
A new process has been developed for the highly enantioselective catalytic reduction of 2-aroylpyridines and successfully applied to the synthesis of (S)-carbinoxamine (1), a therapeutically important histamine H1 antagonist. Related enantioselective reductions of 4-aroylpyridines and ortho-substituted benzophenones are also described.
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