Association between the maternal serum levels of 19 eicosanoids and pre-eclampsia

详细信息    查看全文

• 作者：Anxiong Long^a ; ^b ; Shungao Ma^b ; Qian Li^a ; Na Lin^c ; Xia Zhan^c ; Shuaijun Lu^d ; Yuli Zhu^e ; Liansheng Jiang^a ; Longyi Tan^a ; ^{longyitandoc@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Eicosanoids ; Epoxyeicosatrienoic acid ; Hydroxyeicosatetraenoic acid ; Leukotriene B4 ; Pre-eclampsia
• 刊名：International Journal of Gynecology and Obstetrics
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：133
• 期：3
• 页码：291-296
• 全文大小：538 K

文摘

To investigate whether serum levels of 19 eicosanoids are associated with pre-eclampsia.

Methods

A case–control study was performed using data for pregnant women with pre-eclampsia, normotensive pregnant women, and nonpregnant women, for all of whom serum samples had been collected at a hospital in Shanghai, China, between December 2012 and December 2013. Ultra-performance liquid chromatography–tandem mass spectrometry was used to measure the serum levels of 19 eicosanoids.

Results

Overall, 49 pregnant women with pre-eclampsia, 26 normotensive pregnant women, and 14 nonpregnant women were included. Women with pre-eclampsia had significantly higher serum levels of 11,12-epoxyeicosatrienoic acid (11,12-EET), the hydroxyeicosatetraenoic acids 5-HETE, 8-HETE, 12-HETE, and 15-HETE, and leukotriene B4 than did women with a normal pregnancy and nonpregnant women, both before and after the onset of pre-eclampsia (P < 0.01 for all comparisons). Women with severe pre-eclampsia had significantly higher serum levels of 5-HETE, 15-HETE, and leukotriene B4 than did women with mild pre-eclampsia, women with a normal pregnancy, and nonpregnant women (P < 0.01 for all comparisons).

Conclusion

The eicosanoids 11,12-EET, 5-HETE, 8-HETE, 12-HETE, 15-HETE, and leukotriene B4 might play important parts in the occurrence and development of pre-eclampsia.