Propensity of pneumococcal carriage serotypes to infect the lower airways of children with chronic endobronchial infections

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• 作者：Kim M. Hare^a ; ^{Kim.Hare@menzies.edu.au} ; Heidi C. Smith-Vaughan^a ; Anne B. Chang^a ; ^b ; Susan Pizzutto^a ; Helen L. Petsky^b ; Gabrielle B. McCallum^a ; Amanda J. Leach^a
• 关键词：AOM ; acute otitis media ; BAL ; bronchoalveolar lavage ; CFU ; colony forming units ; CI ; confidence interval ; CSLD ; chronic suppurative lung disease ; IPD ; invasive pneumococcal disease ; MARS ; monitoring antibiotic resistance and serotypes ; NP ; nasopharyngeal ; NT ; Northern Territory ; NTHi ; nontypeable Haemophilus influenzae ; OR ; odds ratio ; PBB ; protracted bacterial bronchitis ; PCV ; pneumococcal conjugate vaccine ; PHiDCV ; 10-valent pneumococcal H. influenzae protein D conjugate vaccine ; Qld ; Queensla
• 刊名：Vaccine
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：35
• 期：5
• 页码：747-756
• 全文大小：1235 K
• 卷排序：35

文摘

The first study to report serotype ‘infectiveness’ in non-invasive lung disease. NP carriage serotypes have a similar propensity to cause lower airway infection. Improved vaccines are needed to prevent non-invasive pneumococcal lung disease.