Treponema pallidum flagellin FlaA2 induces IL-6 secretion in THP-1 cells via the Toll-like receptor 2 signaling pathway

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• 作者：Yafeng Xie^a ; ^b ; ¹ ; Man Xu^a ; ¹ ; Yongjian Xiao^a ; ^b ; Zhuoran Liu^a ; ^b ; Chuanhao Jiang^a ; Xingxing Kuang^a ; Chuan Wang^a ; Haiying Wu^b ; Jing Peng^b ; Chun Li^b ; Yu Wang^b ; Huaming Liu^b ; Bin Liu^b ; Xiaotuan Zhang^b ; Feijun Zhao^a ; Tiebing Zeng^a ; Shuangquan Liu^c ; Yimou Wu^a ; ^{yimouwu@sina.com}
• 关键词：Treponema pallidum ; IL-6 ; Flagellin FlaA2 ; Human monocytic cells ; TLR2 signaling ; Inflammation
• 刊名：Molecular Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：81
• 期：Complete
• 页码：42-51
• 全文大小：2110 K
• 卷排序：81

文摘

Recombinant T. pallidum flagellin FlaA2 was purified. Stimulation with T. pallidum flagellin FlaA2 may significantly induce proinflammatory cytokine IL-6 expression in human monocytes. T. pallidum flagellin FlaA2 induces IL-6 production via signaling pathways involving TLR2, MyD88, ERK, p38, and NF-κB in monocytes, which could contribute to the pathogenesis of T. pallidum.