Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel
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- 作者：Sayaka Sobuea ; Naoki Mizutania ; Yuka Aoyamaa ; Yoshiyuki Kawamotoa ; Motoshi Suzukib ; Yoshinori Nozawac ; Masatoshi Ichiharaa ; Takashi Muratea ; murate@isc.chubu.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Paclitaxel resistance ; Human prostate cancer cell line ; Cabazitaxel ; Cell growth inhibition ; p21 ; Acetylated α-tubulin
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：28 October 2016
- 年：2016
- 卷：479
- 期：4
- 页码：808-813
- 全文大小：1039 K
文摘
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PC3-PR but not PC3 cells are resistant with paclitaxel (PTX).
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PTX-resistance of PC3-PR was not due to MDR1 and MRP1 overexpression.
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PTX could not induce p21 and acetylated α tubulin expression of PC3-PR cells.
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Cabazitaxel and HDAC inhibitor induced p21 and acetylated α-tubulin of PC3-PR.
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Cabazitaxel and HDAC inhibitor equally suppressed PC3-PR cell growth.