Azithromycin impairs TLR7 signaling in dendritic cells and improves the severity of imiquimod-induced psoriasis-like skin inflammation in mice
详细信息 查看全文
- 作者：Shi-Wei Huanga ; 1 ; Yi-Ju Chenb ; c ; 1 ; Sin-Ting Wangd ; Li-Wei Hod ; e ; Jun-Kai Kaod ; e ; Miwako Naritaf ; g ; Masuhiro Takahashif ; Chun-Ying Wuc ; h ; Hsuan-Yu Chengd ; Jeng-Jer Shieha ; d ; i ; shiehjj@vghtc.gov.tw" class="auth_mail" title="E-mail the corresponding author ; shiehjj@dragon.nchu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Azithromycin ; Imiquimod ; Toll-like receptor 7 ; Psoriasis
- 刊名：Journal of Dermatological Science
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：84
- 期：1
- 页码：59-70
- 全文大小：775 K
文摘
- •
Azithromycin (AZM) decreased the expression of co-stimulatory proteins and cytokines secretion in TLR7- activated dendritic cells.
- •
AZM inhibited lysosomal acidification and disrupting proteolytic processing of TLR7 in imiquimod (IMQ) treated dendritic cells.
- •
In IMQ-induced psoriasis-like mouse model, AZM decreased the IMQ-induced skin inflammation, reduced the hyperproliferation and restored the terminal differentiation of keratinocytes and decreased the accumulation of infiltrating immune cells in psoriatic skin.
- •
AZM improved splenomegaly, diminished the Th17 cell population and reduced the expression of cytokines that are crucial for psoriasis in the skin and spleen.