Tissue plasminogen activator deficiency preserves neurological function and protects against murine acute ischemic stroke
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- 作者：Hon-Kan Yipa ; b ; c ; d ; 1 ; Chun-Man Yuene ; 1 ; Kuan-Hung Chenf ; Han-Tan Chaia ; Sheng-Ying Chunga ; Meng-Shen Tonga ; Sheng-Yi Chena ; Gour-Shenq Kaoa ; Chih-Hung Cheng ; Yi-Ling Chena ; Tien-Hung Huanga ; Cheuk-Kwan Sunh ; Mel S. Leei ; mellee@cgmh.org.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Plasminogen activator (tPA) deficiency ; Brain ischemic stroke ; Oxidative stress ; Inflammation ; Apoptosis ; Angiogenesis
- 刊名：International Journal of Cardiology
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：205
- 期：Complete
- 页码：133-141
- 全文大小：1595 K
文摘
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tPA deficiency impeded intracerebral bleeding through reducing MMP-9 activity after acute IS.
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Inhibiting tPA-gene expression protected brain function from acute IS injury.
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tPA deficiency predicted prognostic outcomes after acute IS.