PFKFB3-mediated glycolysis is involved in reactive astrocyte proliferation after oxygen-glucose deprivation/reperfusion and is regulated by Cdh1
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- 作者：Youyou Lv ; Bo Zhang ; Chunchun Zhai ; Jin Qiu ; Yue Zhang ; Wenlong Yao ; wlyao82@126.com" class="auth_mail" title="E-mail the corresponding author ; Chuanhan Zhang ; chzhang@tjh.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：PFKFB3 ; Astrocyte ; Oxygen-glucose deprivation ; Proliferation ; Glycolysis ; Cdh1
- 刊名：Neurochemistry International
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：91
- 期：Complete
- 页码：26-33
- 全文大小：2063 K
文摘
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Astrocyte proliferation after OGD/R is accompanied with PFKFB3 upregulation.
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PFKFB3 siRNA decreases glycolysis and inhibits proliferation of astrocyte after OGD/R.
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Cdh1 inhibits reactive astrocyte proliferation by down-regulating PFKFB3.