Cell enrichment-free massive ex-vivo expansion of peripheral CD20+ B cells via CD40-CD40L signals in non-human primates
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- 作者：Jung-Sik Kima ; b ; c ; d ; 1 ; xenografts@hanmail.net" class="auth_mail" title="E-mail the corresponding author ; Nari Byuna ; b ; d ; f ; g ; 1 ; nr.byun@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Hyunwoo Chunga ; b ; d ; f ; g ; ramzawoo@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Hyun-Je Kima ; b ; d ; f ; g ; tte9801@hanmail.net" class="auth_mail" title="E-mail the corresponding author ; Jong-Min Kima ; b ; c ; vinaka00@cbnu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Taehoon Chunh ; tchun@korea.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Won-Woo Leea ; b ; c ; d ; f ; g ; wonwoolee@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Chung-Gyu Parka ; b ; c ; d ; e ; f ; g ; chgpark@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; chgpark@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：B cell ; Ex-vivo expansion ; Monkeys ; CD40-CD40L signals
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：22 April 2016
- 年：2016
- 卷：473
- 期：1
- 页码：92-98
- 全文大小：1728 K
文摘
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Massive ex-vivo expansion of monkey CD20+ B cells via continuous stimulation of CD40.
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The simple B cell expansion protocol obviating prior cell-enrichment procedures.
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Reproducible B cell expansion rates higher than those previously reported.
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Over 99% purity of expanded B cells through optimized protocol.
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Useful tools for studying monkey B cells and cell-based therapeutic modalities.
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