Isolation and biochemical characterization of a gamma-type phospholipase A2 inhibitor from Macropisthodon rudis snake serum
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- 作者：Lipeng Zhonga ; zhongliborn@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Chunhong Huangb ; merlyhuang@sohu.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Agkistrodon acutus ; Snake venom phospholipaseA2 ; phospholipaseA2 inhibitors ; Macropisthodon rudis ; Inflammation ; Antibacterial
- 刊名：Toxicon
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：1-6
- 全文大小：1051 K
文摘
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Isolation of a novel gamma-type PLA2 inhibitory protein from Macropisthodon rudis snake serum.
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The amino acid sequences of the cDNAs were analyzed with other related inhibitors by multiple sequence alignment.
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Phylogenetic trees were constructed to study their evolutionary relationship.
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PLIγ neutralizes the enzymatic, inflammatory, and antibacterial activities of a PLA2 isolated from Agkistrodon acutus.
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