β2-adrenergic receptor signaling promotes pancreatic ductal adenocarcinoma (PDAC) progression through facilitating PCBP2-dependent c-myc expression
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- 作者：Chunhua Wana ; b ; c ; 1 ; Chen Gonga ; b ; 1 ; Haifeng Zhanga ; Lu Huaa ; Xiaohong Lia ; Xudong Chend ; Yinji Chene ; Xiaoling Dinga ; Song Hed ; Wei Caoa ; Yingying Wangb ; Shaoqing Fana ; Ying Xiaoa ; Guoxiong Zhoua ; zhougx@ntu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Aiguo Shenb ; Shen_aiguo@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：β2-AR ; PCBP2 ; c-myc ; Pancreatic cancer ; Proliferation
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：373
- 期：1
- 页码：67-76
- 全文大小：2519 K
文摘
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Activated β2-AR interacts with PCBP2 in pancreatic cancer cells.
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β2-AR promotes c-myc expression in PDAC cells in a PCBP2-dependent manner.
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β2-AR and PCBP2 are upregulated in human pancreatic cancer tissues.
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High levels of β2-AR/PCBP2 predict poor prognosis in pancreatic cancer patients.