Zinc oxide nanoparticles induce renal toxicity through reactive oxygen species
详细信息 查看全文
- 作者：Lu Xiao1 ; Chunhua Liu1 ; Xiaoniao Chen ; Zhuo Yang ; zhuoyang@nankai.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apoptosis ; Nanoparticles of zinc oxide ; Nephrin ; Podocytes ; ROS
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：90
- 期：Complete
- 页码：76-83
- 全文大小：2751 K
文摘
- •
ZnO NPs decreased the viability of podocytes.
- •
ZnO NPs decreased SOD level and increased MDA level in podocytes.
- •
ZnO NPs induced accumulation of ROS and the apoptosis of podocytes.
- •
ZnO NPs induced kidney toxicity via oxidative stress.
- •
Results showed that ZnO NPs damaged antioxidase in vitro and in vivo.