MEK/ERK signaling is involved in the role of VEGF and IGF1 in cardiomyocyte differentiation of mouse adipose tissue-derived stromal cells

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• 作者：Chunhui Wang¹ ; Wenhui Liu¹ ; Xianning Zhang ; Yinghui Wang ; Huan Liu ; Haifang Li ; ^{hfli1228@163.com}
• 关键词：BATDCs ; brown adipose tissue-derived stromal cells ; WATDCs ; white adipose tissue-derived stromal cells ; VEGF ; vascular endothelial growth factor ; IGF1 ; insulin-like growth factor 1 ; GATA4 ; GATA binding protein 4 ; cTnT ; cardiac Troponin T
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：228
• 期：Complete
• 页码：427-434
• 全文大小：1227 K
• 卷排序：228

文摘

BATDCs, but not WATDCs, could spontaneously differentiate into cardiomyocytes. VEGF and IGF1 were critical factors for such difference in differentiation. VEGF and IGF1 could be used to induce efficient cardiac differentiation of WATDCs. MEK/ERK activation was involved in the role of VEGF and IGF1 on cardiac differentiation.